Sarcopenia and Intervention Physical Therapy

Not Applicable

Not yet recruiting

• Conditions: Sarcopenia

• Registration Number: NCT07013604
• Lead Sponsor: Pharos University in Alexandria

Brief Summary

To evaluate and compare the effectiveness of neuromuscular electrical stimulation (NMES) and low-load resistance training with blood flow restriction (BFR) in improving muscle mass, strength, functional performance, and quality of life in elderly individuals diagnosed with sarcopenia

Detailed Description

Sarcopenia, the age-related decline in muscle mass, strength, and function, significantly affects the health and independence of elderly individuals. It increases the risk of frailty, falls, and disability. Neuromuscular electrical stimulation (NMES) and low-load resistance training with blood flow restriction (BFR) are promising rehabilitation strategies for older adults with limited physical capacity. This study aims to compare the effectiveness of NMES and BFR in managing sarcopenia and improving physical and functional outcomes in the elderly

Study Timeline

• Status Verified: 2025-05
• Study First Submitted: 2025-05-29
• Study First Submitted QC: 2025-06-09
• Last Update Submitted: 2025-06-09
• Study Start: 2025-06-10
• Study First Posted: 2025-06-10
• Last Update Posted: 2025-06-10
• Primary Completion: 2025-08-15
• Study Completion: 2025-09-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Older age (≥ 60-75 years)

Low muscle strength (e.g., low handgrip strength)

Low muscle mass (e.g., ASM/height² below cutoff)

Exclusion Criteria

• heart disese
• kidny disese
• autoimune disese
• cognetive disorder
• sever form of sarcopenia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Change in Muscle Mass	2 month	Assessed using Bioelectrical Impedance Analysis (BIA) to measure skeletal muscle mass.; Evaluation is done pre- and post-intervention to detect changes in the Skeletal Muscle Index (SMI), based on EWGSOP2 criteria

Secondary Outcome Measures

Name	Time	Method
Muscle Strength Handheld dynamometer (e.g., MicroFET)	2 month	Isometric knee extension strength; Measurement: Pre- and post-intervention, using the highest or average value from 2-3 trials.
Timed Up and Go (TUG) Test	2 month	Assesses eight domains of health-related quality of life, scored from 0 to 100. Administered before and after the intervention period