The microcirculation in children treated with extracorporeal membrane oxygenation; an observational longitudinal study - Microcirculatory changes during ECMO

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 90 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Group 1 & 2:
•-Patients admitted to the (neonatal and/or pediatric) IC of Erasmus MC-Sophia, in need of ECMO either due to pathology for which they are primarily admitted or due to secondary pathology which originates during their admittance in the IC.
•- Parental informed consent before ECMO obtained by using the short patient information letter (PIF no. 1; see Ch. 8.2 research protocol) and parental informed consent obtained within 24h after ECMO start obtained by using the regular PIF (PIF no. 2; see Ch. 8.2 research protocol)
•-Patients in group 2 will be matched 1 on 1 to patients in group 1 for gender and age (± 6 months);Group 3:
•- Term patients admitted to the IC of Erasmus MC-Sophia in need of RBC transfusion after surgery (e.g. patients after craniofacial surgery, patients after cardiac surgery)
•- Parental informed consent
•- Patients in group 3 will be matched 1 on 1 to patients in group 1 for gender and age (± 1 month)

•Group 1 & 2:
•- Age * 18 years
•- Rapid response ECMO outside the IC of Erasmus MC-Sophia
•- Transfer on ECMO to the IC of Erasmus MC-Sophia (including the dept. of thoracic surgery of Erasmus MC-Sophia)
•- Unsuccessful cannulation and/or inability to generate sufficient blood flow
•- ECMO exclusion criteria (e.g. weight < 2kg., irreversible pathology);Group 3:
•- Preterm infants
•- Age * 18 years
•- RBC transfusion by irradiated blood cell products
•- RBC transfusion of blood cell savers
•- Term patients diagnosed with malignancy (hematologic and/or solid organ)
•- Term patients diagnosed with hemoglobinopathy of any kind
•- Term patients diagnosed with bone marrow disease of any kind
•- Cardiopulmonary resuscitation and subsequent therapeutic hypothermia
•- Severe pathology which imply abstinence of therapy

发起方