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Clinical Trials/RBR-4jzzh5p
RBR-4jzzh5pCompletedNot Applicable

Microhemodynamic evaluation in children with Severe Sepsis and / or Septic Shock admitted to the IFF-Fiocruz unit of severe patients

Instituto Fernandes Figueira0 sitesStarted: March 2, 2021Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Study OverviewEligibility CriteriaInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Observational

Eligibility Criteria

Ages
1M to 18Y (—)

Inclusion Criteria

  • •Children admitted to the unidadae de pacientes graves (UPG) of Instituto Fernandes Figueira (IFF) Fiocruz; ages between one month and 18 years; diagnosis of severe sepsis or septic shock; indication of mechanical ventilation; in the case of control patients children hospitalized for elective minor surgery.

Exclusion Criteria

  • •Children with body mass below 3kg;contraindications to dark field sidestream device (SDF) assessment as severe bleeding in the sublingual mucosa or malformation of the face that prevented the opening of the mouth;contraindications to indirect calorimetry monitoring or factors that decrease the accuracy of the method such as need for mechanical ventilation with inspired oxygen fraction (FiO2) greater than 85%, need for mechanical ventilation with expiratory pressure at the end of expiration (PEEP) greater than 12 cm H2O; escape around the orotracheal tube expressed by the difference between the inspired tidal volume and the expired tidal volume greater than 10%; presence of bronchopleural fistula; need to use other gases in the mixture such as nitric oxide and heliox; use of respirators with continuous flow; continuous hemodialysis and patients with pulmonary disease with chronic hypercapnia; presence of congenital heart disease; shock from other etiologies; liver cirrhosis, cancer; type I diabetes mellitus and autoimmune rheumatological diseases; conditions that cause microvascular derangements which may confound data analysis; indeterminate or unknown diagnosis time of septic shock; children whose parents or legal guardians did not agree or refused to sign the written informed consent.

Investigators

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