A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease
- Conditions
- Sickle Cell Disease
- Registration Number
- NCT04166526
- Lead Sponsor
- Boston Children's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br>Group 1 (healthy controls):<br><br> - Children ages 8-18 without SCD<br><br>Group 2 (SCD patients without treatment):<br><br> - SCD patients ages 8-18 who:<br><br> - have not undergone gene therapy or a bone marrow transplant<br><br> - are not receiving chronic transfusions<br><br> - have not received a blood transfusion in the past 3 months<br><br>Group 3 (SCD patients who have undergone gene therapy):<br><br> - SCD patients ages 8-18 who have had gene therapy at least one month prior to<br> enrollment<br><br>Group 4 (SCD patients who have chronic transfusions):<br><br> - SCD patients ages 8-18 who receive chronic transfusions<br><br>Exclusion Criteria:<br><br> - Electrical implants such as cardiac pacemakers or perfusion pumps;<br><br> - Ferromagnetic implants such as aneurysm clips, surgical clips, prosthesis,<br> artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near<br> the eye, or steel implants;<br><br> - Ferromagnetic objects such as jewelry or metal clips;<br><br> - Women of childbearing age who are seeking to become pregnant, who are breastfeeding,<br> or who suspect they may be pregnant;<br><br> - Pre-existing medical conditions including a likelihood of developing seizures or<br> claustrophobic reactions;<br><br> - Any greater than normal potential for cardiac arrest;<br><br> - Subjects requiring sedation for MRI
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Accuracy of FDNIRS-DCS in measuring blood oxygenation of the brain
- Secondary Outcome Measures
Name Time Method