An observational neuroimaging and neurophysiological study investigating the visual pathway in Huntington*s disease.

Recruiting

Conditions: hereditary neurodegenerative movement disorder
Huntington's disease
10029299
10028037

Registration Number: NL-OMON45518

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

* Between 18 and 65 years of age at time of visit
* Ability to undergo MRI scanning
* Written informed consent must be obtained from the participant;If the participant is a manifest HD gene carrier:
* Gene positive tested with CAG repeat length of * 36 in the HTT gene
* UHDRS-TMS > 5;If the participant is a premanifest HD gene carrier:
* Gene positive tested with CAG repeat length of * 36 in the HTT gene
* UHDRS-TMS * 5;If the participant is a control subject:
* Gene negative tested for HD or without family history of HD
* No other known cognitive, neurological or psychiatric disorders

Exclusion Criteria

* Impaired primary visual ability (<0.5) or ophthalmic disorders
(including amblyopia or color vision deficiency)
* Additional major co-morbidities not related to HD
(e.g. cardiovascular diseases, hypertension, diabetes mellitus, and/or other neurological disorders)
* History of severe head injury
* Contra-indication for MRI (metallic implants/devices, claustrophobia)
* Participation in intervention trials
* Pregnancy
* Inability to understand the information about the protocol

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* Group differences and correlations between pre- and manifest HD and healthy<br /><br>controls on the functional and structural MRI outcome parameters.<br /><br>* Correlation between scores on neuropsychological assessments and MRI outcome<br /><br>parameters in all groups.<br /><br>* Differences in VEP outcome measures (amplitudes and latencies) between pre-,<br /><br>manifest HD and healthy controls.<br /><br>* Correlation between VEP outcome measures and outcome parameters of different<br /><br>imaging modalities (e.g. fMRI, DTI and structural MRI).</p><br>

Secondary Outcome Measures