Functional neuroimaging and neurophysiological patterns during Zolpidem-induced behavioral improvement in akinetic mutism: a pilot study

Completed

• Conditions: NVT; 10042258

• Registration Number: NL-OMON47472
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 2

Inclusion Criteria

* Diagnosis of AM, caused by non-progressive neurological injury
* Consistent temporarily restored speech and limb movement following administration of 10 mg Zolpidem

Exclusion Criteria

* Ongoing neurodegenerative disease
* Standard MRI scan exclusion criteria (i.e. pacemaker and other metallic foreign bodies contraindicated for MRI)
* Motor agitation interfering with MRI, EEG or MEG
* Anatomical deformities that prevent the subject from undergoing MEG registration in supine position (i.e. thoracic kyphosis)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome of this study is functional change as measured by<br /><br>neuroimaging (structural MRI and fMRI), electrophysiology (EEG), and<br /><br>magneto-encefalography (MEG) before and after administration of Zolpidem. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable. </p><br>