etwork-based functional neuroimaging in cognitive sequelae after concussive brain injury and cognitive training

Not Applicable

Conditions: F07.2
Postconcussional syndrome

Registration Number: DRKS00029388

Lead Sponsor: niklinik KölnKlinik für Neurologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 93

Inclusion Criteria

Medically diagnosed concusion within last 3 weeks
- Deficit in attention and/or memory as well as at least two symptoms as defined by Post-Concussion Syndrome (e.g. headache, numbness, fatigue, irritability, insomnia, noise/light sensitivity).
- Objectifiable cognitive deficit in terms of at least below average cognitive performance (reduction of the total value of the CogBat (Aschenbrenner et al., 2012) by more than one standard deviation below age-corrected norm)
- Age 18-65 years

Exclusion Criteria

- Severe psychiatric or neurological desease in the past
- Frequent use of central operating medicine or drugs
- Lacking capacity to consent
- Deficient knowledge of the german language to perform the intervention
- Contraindication for MRI examination
- Pacemaker, cochlea implant, vascular clip or other metal implant, stimulation device or drug pumps, metal splinters, tatoos
- Nursing, pregnent and women by whom a pregnancy can’t be foreclosed
- Claustrophobia

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total value of cognition, determined by the validated computerbased neuropsychological battery of tests. <br>CogBat (Aschenbrenner, Kaiser, Pfüller, Roesch-Ely, & Weisbrod, 2012) after 4 respectively 16 weeks.<br>

Secondary Outcome Measures

Name	Time	Method
i. Change of functional networks based on global graph parameter (using fMRI resp. qEEG)<br>ii. Total vale of Rivermead Post Concussion Questionaire (RPCQ)<br>iii. Domain scores of attention, memory and executive functions determined by CogBat<br>iv. Subjectively perceived mental performance determined by CogBat[Freitext]<br>v. Nuisance through headache, fatigue resp. insomnia determined by Headache Impact Test-6 (HIT-6), Multidimensional Fatigue Inventory (MFI) resp. Insomnia Severity Index (ISI)<br>vi. Serum level of neurofilament light chain (NFL)<br>