Electrophysiological and functional imaging findings of central nervous representation of copingstrategies and their impact on cognitive performance in patients chronic relapsing pain and normal subjects.
- Conditions
- G43.9Migraine, unspecified
- Registration Number
- DRKS00022777
- Lead Sponsor
- Medizinische Fakultät Mannheim der Universität Heidelberg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 60
Patients:
- Age: 18-40 years
- Patients must meet the diagnostic criteria of migraine with or without ICHD-3 aura
- Other types of headache may exist in addition to migraine if they can be classified differently by the patient
- Migraine episode frequency 1-14/month.
- Migraine history for at least one year. First migraine episode at age <50 years
- Headache diary kept for 3 months before and 1 month after the examinations
- Voluntary, informed consent to participate in the study
Healthy Subjects:
- Age: 18-40 years
- Voluntary, informed consent to participate in the study
Patients:
- Patients must not have any contraindications to MRI examinations.
- Patients must not have claustrophobia in need of treatment
- Patients must not be pregnant. This is ensured by a ß-HCG- test in the urine.
- Patients should be free of pain for at least 48 hours before the test. No pain medication should be taken.
- Patients should not take centrally effective migraine prophylaxis or coanalgesics (especially anticonvulsants) or centrally attenuating substances (especially opioids).
- If a migraine episode occurs in the 24 hours after the measurements, the measurement is stratified as preical.
- Patients must be free of neurological and psychiatric diseases that could affect the outcome of the study. Subclinical depressive or anxiety-related symptoms manifested in BDI and STAI are not exclusion criteria. The exclusion criterion is a higher degree of anamnestic impairment of kidney or liver function.
Test persons:
- No relevant history of episodic headache. Freedom from sporadic headaches for at least 4 weeks before measurement.
- Test persons must not have any contraindications to MRI examinations.
- Test persons must not have claustrophobia requiring treatment
- Test subjects must not be pregnant. This is ensured by a ß-HCG test in the urine.
- The test persons must be free of neurological and psychiatric diseases that could affect the outcome of the study. Subclinical depressive or anxiety-related symptoms manifested in BDI and STAI are not exclusion criteria. The exclusion criterion is a higher degree of anamnestic impairment of kidney or liver function.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differential changes of electrophysiological and Imaging markers of Attention and distraction under painful stimulation between the groups
- Secondary Outcome Measures
Name Time Method Overlap of the methods (EEG/ERPs and fMRI)