NL-OMON53178Not yet recruitingNot Applicable
Stress-induced immune reprogramming in cardiovascular disease (STRESS-CVD) - STRESS-CVD
niversitair Medisch Centrum0 sites125 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 125
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •In order to be eligible to participate in this study, a subject must meet all
- •of the following criteria:
- •- Age 40-70 years
- •- Heightened cardiovascular risk, defined as a moderate to high risk for CVD
- •(>7.5% 10 year ASCVD risk, according to American College of Cardiology (ACC)
- •AtheroSclerotic Cardiovascular Disease (ASCVD) risk calculator
- •(https://tools.acc.org/ASCVD-Risk-Estimator-Plus/#!/calculate/estimate/) or
- •patients with subclinical ASCVD on imaging (e.g. elevated CAC or asymptomatic
- •coronary artery stenosis).
- •- Written informed consent
Exclusion Criteria
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •Previous cardiovascular events (stroke, TIA, myocardial infarction)
- •Heart failure
- •Auto-inflammatory or auto-immune diseases
- •Use of immunomodulating drugs
- •Severe renal failure (MDRD <30)
- •Previous vaccination within 1 months prior to study entry.
- •Current infection or clinically significant infections within 1 months before
- •participation (defined as fever >38.5).
- •Pregnancy/lactation
- •Severe psychiatric disorder.
- •Inability to undergo PET-CT scanning
- •History of hematological malignant disease
- •Documented bleeding diathesis or thrombocytopenia <50 *10e9/L
Investigators
Similar Trials
Recruiting
Not Applicable
Comprehensive Assessment of Interconnection Between Brain Emotional Activity and Coronary Plaque InstabilityAtherosclerosis, CoronaryEmotional StressInflammationHematopoiesisAtherosclerosis Coronary Artery With Angina PectorisAcute Coronary SyndromeAtherosclerosisHeart AtheromaNCT04853511Korea University Guro Hospital200
Not yet recruiting
Not Applicable
nravelling the role of trained immunity in cardiac allograft vasculopathyNL-OMON56885Erasmus MC, Universitair Medisch Centrum Rotterdam200
Completed
Not Applicable
Heart Inflammation and Mental Stress StudyHypertensionNCT03695146University of Miami52
Recruiting
Not Applicable
Modulation of the cardiovascular and immunologic characteristics by aerobic exercise in women with recurrent miscarriagerecurrent miscarriagespontaneous abortions1000021110057166NL-OMON33581niversitair Medisch Centrum Sint Radboud30
Withdrawn
Not Applicable
Steroid-induced Reduction of Surgical Stress StudyCoronary Artery StenosisCoronary Artery Bypass Graft SurgeryNCT00807521Amsterdam UMC, location VUmc
