NL-OMON53178尚未招募不适用
Stress-induced immune reprogramming in cardiovascular disease (STRESS-CVD) - STRESS-CVD
niversitair Medisch Centrum0 个研究点目标入组 125 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 125
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •In order to be eligible to participate in this study, a subject must meet all
- •of the following criteria:
- •- Age 40-70 years
- •- Heightened cardiovascular risk, defined as a moderate to high risk for CVD
- •(>7.5% 10 year ASCVD risk, according to American College of Cardiology (ACC)
- •AtheroSclerotic Cardiovascular Disease (ASCVD) risk calculator
- •(https://tools.acc.org/ASCVD-Risk-Estimator-Plus/#!/calculate/estimate/) or
- •patients with subclinical ASCVD on imaging (e.g. elevated CAC or asymptomatic
- •coronary artery stenosis).
- •- Written informed consent
排除标准
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •Previous cardiovascular events (stroke, TIA, myocardial infarction)
- •Heart failure
- •Auto-inflammatory or auto-immune diseases
- •Use of immunomodulating drugs
- •Severe renal failure (MDRD <30)
- •Previous vaccination within 1 months prior to study entry.
- •Current infection or clinically significant infections within 1 months before
- •participation (defined as fever >38.5).
- •Pregnancy/lactation
- •Severe psychiatric disorder.
- •Inability to undergo PET-CT scanning
- •History of hematological malignant disease
- •Documented bleeding diathesis or thrombocytopenia <50 *10e9/L
研究者
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