Heart Inflammation and Mental Stress Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypertension
- Sponsor
- University of Miami
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Change in heart rate variability
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of the study is to investigate the neural underpinnings of cardiovascular reactivity to mental stress as a function of HIV and hypertensive risk.
Detailed Description
The main objectives of the study are to assess (1) patterns of brain activity/connectivity that confers greater cardio-autonomic/emotion regulation, (e.g., heart rate variability, blood pressure reactivity, inflammatory-immune activation, etc.), during rest, mental stress, and anger-related distress, (2) whether changes in breathing pace mitigate task-based effects on cardio-autonomic-immune regulation, and (3) whether these patterns vary as a function of HIV or pre-hypertensive (HTN) status-related changes to the brain structures underlying cardioautonomic and emotion regulation.
Investigators
Roger McIntosh
Assistant Professor
University of Miami
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change in heart rate variability
Time Frame: Baseline, pre-intervention and up to 60 minutes post-intervention
Heart rate variability will be measured using a standard electrocardiogram to detect variability in R -to-R intervals.
Secondary Outcomes
- Change in cytokine expression in peripheral blood mononuclear cells(Baseline, pre-intervention and up to 60 minutes post-intervention)