Stressor-evoked Brain and Cardiovascular Responses to Acute Psychological Stress

Not Applicable

Completed

• Conditions: Acute Psychological Stress

• Registration Number: NCT05413512
• Lead Sponsor: Baylor University

Brief Summary

The present study will examine cardiovascular, metabolic, and neural responses to acute psychological stress using a cross-sectional approach.

Detailed Description

All participants in this study will undergo an acute psychological stress paradigm, consisting of two acute psychological stress tasks (MSIT and Stoop). There is no formal randomization since al participants are randomized to undergo the acute psychological stress tasks.

Study Timeline

• Study Start: 2020-03-02
• Primary Completion: 2021-09-30
• Study Completion: 2021-09-30
• Study First Submitted: 2022-06-05
• Study First Submitted QC: 2022-06-07
• Study First Posted: 2022-06-10
• Results First Submitted: 2022-12-21
• Status Verified: 2025-06
• Results First Submitted QC: 2025-06-23
• Last Update Submitted: 2025-06-23
• Results First Posted: 2025-06-24
• Last Update Posted: 2025-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 170

Inclusion Criteria

• 18-30 years old

Exclusion Criteria

• Chronic medical or neurological condition
• Pregnant
• Current illness or infection
• Any condition that would prohibit engaging in physical exercise
• Any metal implants in body
• Claustrophobia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline)	18 minutes (approximately 9 minutes for each task)	Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline).
Heart Rate (Bpm) Measured by Electrocardiogram	18 minutes (approximately 9 minutes for each stress task)	Stressor-evoked heart rate. (Heart rate during acute psychological stress task - Heart rate during resting baseline).
Neural Activity Measured by fMRI	18 minutes (approximately 9 minutes for each stress task).	Stressor-evoked neural activity.; Incongruent-vs-Congruent t at the group-level, filtered at 0.05 after FDR correction and with a cluster extent of 50 voxels.

Trial Locations

Locations (1)

Baylor University; 🇺🇸 Waco, Texas, United States