Breathing & Blood Pressure
Overview
- Phase
- Not Applicable
- Intervention
- Adults without obesity
- Conditions
- Healthy
- Sponsor
- Florida State University
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Blood pressure during exercise
- Status
- Recruiting
- Last Updated
- 3 months ago
Overview
Brief Summary
The purpose of this study is to determine the effect of obesity on cardiovascular responses during various breathing maneuvers.
Detailed Description
Adults with higher body mass can have trouble breathing during exercise, which could be due to high respiratory muscle workloads. These breathing muscles can require a lot of energy, which takes away energy from other (e.g., leg) muscles. Participating in this study will help us understand how the heart and blood vessels respond during brief exercise and during various breathing maneuvers.
Investigators
Joseph Watso
Assistant Professor
Florida State University
Eligibility Criteria
Inclusion Criteria
- •Body mass index values of ≤40 kg/m\^2
Exclusion Criteria
- •Not weight stable (\<5% change in body mass over the past six months)
- •Overt cardiovascular, neurological, renal, liver, and/or metabolic illness (e.g., diabetes mellitus)
- •Current, or history of uncontrolled, Stage 2 hypertension (blood pressure \>140 / 90 mmHg; anti-hypertensive medications are permitted)
- •Diagnosed obstructive sleep apnea
- •Previous bariatric surgery
- •Diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s)
- •Current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping)
- •Per the POWERbreathe® company:
- •Patients who have undergone recent abdominal surgery and those with abdominal hernia.
- •Asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnoea.
Arms & Interventions
Adults without obesity
body mass index below 30 kg/m\^2
Adults with obesity
body mass index above 30 kg/m\^2
Outcomes
Primary Outcomes
Blood pressure during exercise
Time Frame: Up to one week
Systolic and diastolic blood pressure measured in the laboratory at rest and during an incremental aerobic exercise test
Secondary Outcomes
- Blood pressure during respiratory muscle testing(Up to one week)