Breathing & Blood Pressure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Blood pressure during exercise
研究概览
简要总结
The purpose of this study is to determine the effect of obesity on cardiovascular responses during various breathing maneuvers.
详细描述
Adults with higher body mass can have trouble breathing during exercise, which could be due to high respiratory muscle workloads. These breathing muscles can require a lot of energy, which takes away energy from other (e.g., leg) muscles. Participating in this study will help us understand how the heart and blood vessels respond during brief exercise and during various breathing maneuvers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body mass index values of ≤40 kg/m^2
排除标准
- •Not weight stable (<5% change in body mass over the past six months)
- •Overt cardiovascular, neurological, renal, liver, and/or metabolic illness (e.g., diabetes mellitus)
- •Current, or history of uncontrolled, Stage 2 hypertension (blood pressure >140 / 90 mmHg; anti-hypertensive medications are permitted)
- •Diagnosed obstructive sleep apnea
- •Previous bariatric surgery
- •Diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s)
- •Current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping)
- •Per the POWERbreathe® company:
- •Patients who have undergone recent abdominal surgery and those with abdominal hernia.
- •Asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnoea.
- •If a patient is suffering from a ruptured eardrum or any other condition of the ear.
- •Patients with marked elevated left ventricular end-diastolic volume and pressure.
- •Patients with worsening heart failure signs and symptoms after a respiratory/inspiratory muscle training (IMT) session
- •If you are suffering from a cold, sinusitis, or respiratory tract infection, we advise that you do not use your POWERbreathe IMT device.
- •Individuals who are not yet adults (infants, children, teenagers)
- •Pregnant (self-reported and urine pregnancy test conducted), lactating (self-reported), or post-menopausal (self-reported) females
- •Prisoners
研究组 & 干预措施
Adults without obesity
body mass index below 30 kg/m^2
Adults with obesity
body mass index above 30 kg/m^2
结局指标
主要结局
Blood pressure during exercise
时间窗: Up to one week
Systolic and diastolic blood pressure measured in the laboratory at rest and during an incremental aerobic exercise test
次要结局
- Blood pressure during respiratory muscle testing(Up to one week)
研究者
Joseph Watso
Assistant Professor
Florida State University