The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation

Not Applicable

Completed

• Conditions: Heart Failure; Resistance Training; Coronary Artery Disease

• Registration Number: NCT05391620
• Lead Sponsor: Université Libre de Bruxelles

Brief Summary

The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population.

3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of \~ 70% of one repetition maximal (1RM).

Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes.

The investigators collect blood sample before exercice, after HIIT and after RT.

It is randomized cross-over study.

Detailed Description

The subjects come on two different days minimum 2 days and maximum 10 days between the two tests. They were instructed to avoid exercise the day before they participated in the study.

The investigators collect blood 2 minutes after endurance training (HIIT) and 2 min after RT training.

Study Timeline

• Study Start: 2022-02-22
• Study First Submitted: 2022-04-07
• Study First Submitted QC: 2022-05-20
• Study First Posted: 2022-05-26
• Primary Completion: 2022-06-10
• Study Completion: 2022-10-25
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-13
• Last Update Posted: 2024-02-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 25

Inclusion Criteria

• Clinical Coronary artery diseases
• Heart failure with reduced ejection fraction

Exclusion Criteria

• angina
• acutely decompensated heart failure
• electrocardiographic evidence of ischemia
• significant valvular disease
• orthopedic/neurologic disorders that limited exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
change in Testosterone	within 2 minutes after TR training session on day 1	nmol/l
change in ph	within 2 minutes after TR training session on day 1	venoust
Change in Lactate	within 2 minutes after TR training session on day 1	mmol/l
change PCO2 venoust	within 2 minutes after TR training session on day 1	mm Hg
change Glucocorticoid Cortisol	within 2 minutes after TR training session on day 1	nmol/l
change in Growth Hormone	within 2 minutes after TR training session on day 1	ng/ml

Secondary Outcome Measures

Name	Time	Method
Pleasure of the session scale	within 4 minutes after TR training session on day 1	0 = worse 10 = better
Borg scale	within 4 minutes after TR training session on day 1	Borg Rating of Perceived Exertion - Borg modified (0 = no exertion at all -10 maximal exertion)

Trial Locations

Locations (1)

Erasme Hospital; 🇧🇪 Brussels, Belgium