Adiponectin and Ethnic Differences in Insulin Resistance

Completed

• Conditions: Insulin Resistance; Type 2 Diabetes
• Interventions: Other: none- observational study

• Registration Number: NCT01831102
• Lead Sponsor: University of Colorado, Denver

Brief Summary

The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. The investigators also aimed to examine associations between nutritional factors and adiponectin levels.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Status Verified: 2013-04
• Study First Submitted: 2013-04-05
• Study First Submitted QC: 2013-04-09
• Last Update Submitted: 2013-04-09
• Study First Posted: 2013-04-15
• Last Update Posted: 2013-04-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• 18-60 years of age
• BMI 20.0-34.9 m/kg2
• Mexican American with at least 3 grandparents born in Mexico or white with no grandparents of Latino descent.

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Exclusion Criteria

• pregnancy
• breastfeeding
• diabetes mellitus
• blood pressure > 160/100 mmHg
• creatinine > 1.5 mg/dl or glomerular filtration rate (GFR) < 60
• liver function tests > 3x upper limit of normal (ULN)
• h/o heart failure
• h/o eating disorder

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non-Latino white	none- observational study	no Latino ancestry, Caucasian
Mexican American	none- observational study	Mexican American ancestry

Primary Outcome Measures

Name	Time	Method
total adiponectin concentration	measured once during second study visit, in fasting condition

Secondary Outcome Measures

Name	Time	Method
Insulin sensitivity	Measured once, during second study visit.	Calculated from insulin and glucose values obtained during IV glucose tolerance test.

Trial Locations

Locations (1)

University of Colorado Anschutz Medical Center; 🇺🇸 Aurora, Colorado, United States