Simultaneous Integrated Boost Technique in Breast Cancer Radiotherapy
- Conditions
- Radiotherapy Side EffectBreast Cancer
- Interventions
- Radiation: Simultaneous integrated boost
- Registration Number
- NCT04535895
- Lead Sponsor
- Medical University of Graz
- Brief Summary
Adjuvant radiotherapy after breast conserving surgery has been shown to improve both local control and overall survival. Dose escalation of the tumor bed by addition of a boost after whole breast radiotherapy reduces the risk of local recurrence in invasive breast cancer.
Simultaneous integrated boost (SIB) techniques have been shown to provide more conformal treatment plans than conventional sequential boost, in addition, SIB enables a reduction in the overall treatment time by 1 week compared to conventional boost techniques.
The proposed study is aimed at evaluating radiation-induced toxicity in patients treated with breast-conserving surgery in combination with radiotherapy using SIB technique.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- Female
- Target Recruitment
- Not specified
- Invasive breast cancer or ductal carcinoma in situ
- Breast conserving surgery
- Complete tumor resection
- Treatment with adjuvant radiotherapy of the breast
- Indication for boost Irradiation
- Given informed consent
- Incomplete tumor resection
- Mastectomy
- Distant metastases at diagnosis
- Unable to give informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Simultaneous integrated boost arm Simultaneous integrated boost -
- Primary Outcome Measures
Name Time Method Acute Radiation induced toxicity (grade 2 or higher) Measurement 3 months after completion of radiotherapy Toxicity score using Common Terminology for Adverse Events (CTCAE)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Medical University of Graz
🇦🇹Graz, Austria