Risk of Diabetes in Young Turner Syndrome Patients
- Conditions
- Turner Syndrome
- Registration Number
- NCT02160717
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Brief Summary
Turner Syndrome is a common genetic disorder. Seventy percent of adults with Turner Syndrome have abnormalities in glucose metabolism which can lead to diabetes. The current screening guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood sugar once a year. The objective of this study is to determine if there are abnormalities in glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin) is more prevalent in girls with Turner Syndrome compared to healthy controls.
- Detailed Description
The study will be conducted at Children's Hospital Medical Center, Cincinnati. The study will require 1 visit to the hospital where the subject will have an oral glucose tolerance test and a physical exam
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 120
- Turner Syndrome confirmed by chromosomal testing
- On standard therapy (growth hormone and or estrogen)
- Type 1 or Type 2 diabetes
- Polycystic Ovarian Syndrome
- Pregnancy
- On any medications that alter blood sugar
Healthy Female Controls:
Inclusion Criteria:
- Healthy
Exclusion Criteria:
- Type 1 or Type 2 diabetes
- Polycystic Ovarian Syndrome
- Pregnancy
- On any medications that alter blood sugar
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Beta-Cell Function measured as Disposition Index 1 day at screening Disposition index will be calculated based on the results of the oral glucose tolerance test using minimal modeling (computer program)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Children's Hospital Medical Center, Cincinnati
🇺🇸Cincinnati, Ohio, United States