Effect of scorpion bite on success of spinal anaesthesia
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2022/11/047113
- Lead Sponsor
- Indian Council of Medical Research Department of Health Research (ICMR)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adult ASA I, II patients undergoing elective surgery under proposed spinal anaesthesia, involving patients with a history of scorpion bite/s and without such a history.
Exclusion Criteria
1. Emergency surgeries
2. Anomalies of vertebral column
3. Blood or CSF tap during the procedure
4. Patient on anti-coagulants or with bleeding diathesis
5. Patientâ??s refusal to procedure
6. Patients with psychological disorders
7. Patients with opioid abuse/ dependency
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Incidence of failed subarachnoid block <br/ ><br>2.Time of onset of sensory and motor blockade after subarachnoid block <br/ ><br>3.Peaks of sensory and motor block, assessed by pin prick method and modified Bromage method respectively. <br/ ><br>4.Study of voltage gated sodium channels to see for mutations. <br/ ><br>Timepoint: For Primary Outcome No:- <br/ ><br>1,2,3 Baseline, 2 minutes, 4 minutes, 6 minutes, 8 minutes, 10 minutes,12 minutes,14 minutes, 16 minutes, 18 minutes and 20 minutes. <br/ ><br>2.Batch testing of 10 blood samples for Genotyping of Voltage-gated sodium channels gene would be done. <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1. Time needed for onset of adequate sensory and motor blockade after subarachnoid block <br/ ><br>2.Association of mutations in sodium channel with failed subarachnoid block. <br/ ><br> <br/ ><br>Timepoint: For secondary outcomes no:- <br/ ><br>1. baseline, 2 min, 4 min, 6 min, 8 min, 10 min, 12 min, 16 min, 18 min, 20 minutes after spinal anesthesia <br/ ><br>2. 3 month, 6 month, 9 month, 12 month, 15 month, 18 month, 24 months from start of the study