Observing the Changes of Endocrine and Metabolism in Patients With Thalassemia Major
- Conditions
- Thalassemia Major
- Registration Number
- NCT03951818
- Lead Sponsor
- National Taiwan University Hospital
- Brief Summary
Patient with thalassemia major have many endocrine diseases, such as hypopituitarism, hypothyroidism, hypoparathyroidis, osteoporosis, and etc.. These problems may be due to anemia itself or related to iron deposition. This study aimed to investigate the endocrine aspect of thalassemia major patients in Taiwan in order to introduce early intervention or treatment in the future.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- Clinical diagnosis of Thalassemia major
- Patients of 20-85 years old
- Patients younger than 20 years old.
- Patients older than 85 years old.
- Patients who are pregnant
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Abnormal bone mineral density rate 10 years abnormal bone mineral density is defined as T-score \< -1 SD in menopause women or men older than 50 years old, or Z score \< -2 SD in premenopausal women or men not older than 50 year old.
- Secondary Outcome Measures
Name Time Method abnormal thyroid function rate 10 years abnormal thyroid function is defined as abnormal free thyroxine or abnormal thyrotropin. Normal range of free thyroxine is 0.6-1.75 ng/dl. normal range of thyrotropin is 0.1-4.5 mU/l.
abnormal pituitary function rate 10 years abnormal pituitary function is defined as any of the abnormality in serum adrenocorticotropin (pg/l), IGF-1 (ng/ml). thyrotropin (mU/l), FSH (U/l), LH (U/l)
Trial Locations
- Locations (1)
Shyang-Rong Shih
🇨🇳Taipei, Taiwan