Changes in plasma metabolomes & effects of ONS in thalassemia with malnutritio

Phase 2

Completed

• Conditions: Metabolomic in thalassemia with manutrition; NT-2013, metabolomic, thalassemia, malnutrition

• Registration Number: TCTR20220802003
• Lead Sponsor: Faculty of Medicine, Chiang Mai University

Brief Summary

The prevalence of malnutrition in adult thalassemia was 20%. Plasma metabolomic profile suggested that the malnourished thalassemia had imbalanced proteolysis and deregulation of acylcarnitine derivatives that were associated with decreased fatty acid oxidation. ONS improved nutritional status and fatty acid oxidation in malnourished thalassemia.

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-01-31
• Study Start: 2022-08-02
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Thalassemia patient diagnosed by HPLC method
2. Accept to enrollment and give an inform consent

Exclusion Criteria

1. Inherited metabolic disorders
2. Liver disease
3. Renal parenchymal disease (eGFR < 60)
4. Other hemolytic anemia
5. Multiple myeloma
6. Malignancy
7. Active infection
8. Chronic alcohol drinking

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of malnutrition 0 weeks Nutrition assessment 2013

Secondary Outcome Measures

Name	Time	Method
Changes of anthropometry 12 weeks Anthropometric measurement,Changes of Plasma metabolomic 12 weeks LC coupled with quadrupole time-of-flight MS (LC/Q-TOFMS) ,Changes of NT-2013 12 weeks NT-2013,Changes of TMAO 12 weeks Plasma