Preterm brain injury, long-term outcome and brain development study

Completed

• Conditions: brain development; Preterm brain injury; 10010335; 10028920

• Registration Number: NL-OMON47239
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-11-29
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 67

Inclusion Criteria

VPT children (GA<32 weeks), born between May 2006 and October 2007, who participated in a previous longitudinal cohort study on neonatal brain imaging and short term outcome, and who underwent MRI examination at TEA

Exclusion Criteria

Lack of informed consent of parents (including parental refusal or unable to explain because of language barrier)
Congenital or acquired abnormalities of the central nervous system, other than those caused by preterm birth
Any medical condition, device or implant that pauses a safety issue for MRI examination (exclusion for MRI investigation)
Children in whom a proper preparation for the MRI or EEG procedure is not possible because of severe motor, behavioural or cognitive handicaps or severe anxiety (both for MRI and EEG examination)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Relationship between common structural neonatal MRI abnormalities (white matter<br /><br>injury and cerebellar injury) and neurodevelopmental outcome on different<br /><br>domains (i.e. neuromotor outcome, cognitive outcome, neuropsychological<br /><br>outcome, executive functions and behavioural outcome) 9-10 years after preterm<br /><br>birth.<br /><br>Relationship between neonatal MRI findings and brain development (i.e. brain<br /><br>tissue growth and markers of brain maturation ) and connectivity (EEG and fMRI)<br /><br>10 years after preterm birth.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Relationship between brain development and connectivity 9-10 years after<br /><br>preterm birth and motor, cognitive, neuropsychological, executive and<br /><br>behavioural functioning.</p><br>