ong-term neurodevelopmental outcome after perinatal arterial ischemic stroke

Completed

• Conditions: perinatal arterial ischemic stroke (PAIS); neonatal stroke; 10007963; 10028920

• Registration Number: NL-OMON55959
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

- Children admitted to the NICU of the WKZ between September 2009 and March
2016 (aged 8-14 years during study participation), and diagnosed with PAIS with
MRI;
- Participant of the Neonatal Stroke Registry Utrecht;
- Born at >=34 weeks of gestation;
- A neonatal MRI was performed and is available for analysis.

Exclusion Criteria

- Preterm-born infants born before 34 weeks of gestation;
- Other severe structural brain damage previously confirmed by neuro-imaging;
- Congenital brain abnormalities and/or other (chromosomal/metabolic) anomalies;
- Acquired brain injury due to trauma or infection

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint will be neurodevelopmental, behavioral, executive, and<br /><br>language functioning after perinatal arterial ischemic stroke at 8-14 years of<br /><br>age.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints will be brain growth and connectivity at school age after<br /><br>PAIS, the relation between neurodevelopmental outcomes and lesion topology,<br /><br>brain growth and connectivity, and changes in the rate of neurodevelopmental<br /><br>impairment after PAIS over time.</p><br>