ormal fetal neurodevelopment; healthy control population as a comparison for fetuses with a congenital heart disease
Recruiting
- Conditions
- Congenital heart diseaseIntra-uterine neurodevelopmental disorders
- Registration Number
- NL-OMON26893
- Lead Sponsor
- eiden University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 70
Inclusion Criteria
Singleton pregnancy
- Normal second trimester ultrasound (absence of abnormalities on ultrasound)
- No use of alcohol, drugs or other psychoactive substances during pregnancy
- Age = 18 years
- Gestational age 18-36 weeks
Exclusion Criteria
- Obstetric history of intra-uterine growth restriction or intra-uterine fetal demise
- Serious underlying maternal medical condition
- Use of teratogenic medication during pregnancy
- Congenital abnormalities detected in the first year of life
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Brain age of healthy control fetuses, especially in the third trimester (cortical folding of the brain)<br>2. Speed of maturation of healthy control fetuses, especially in the third trimester
- Secondary Outcome Measures
Name Time Method 1. Brain perfusion of healthy control fetuses<br>2. Growth trajectories of brain structures<br>3. Brain volume of healthy control fetuses<br>4. Collection of placentas and biomaterial of the umbilical cords for storage for future research. The biomaterials will be stored in the LUMC Biobank Verloskunde