The Role of Narrowband Ultraviolet B Exposure in the Maintenance of Vitamin D Levels During Winter
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 37
- 试验地点
- 4
- 主要终点
- 25(OH)D level
研究概览
简要总结
The investigators investigated the ability of narrowband ultraviolet B (nbUVB) treatment in the maintenance of vitamin D levels achieved during the summer in Finland. The investigators randomized 37 subjects into groups of 17 and 18 subjects. The other group received 2 standard erythema doses (SED) nbUVB exposure every other week until week 24, and serum 25(OH)D levels were measured at the onset and at weeks 6, 14, 20, 26 and 30. The control group was not illuminated and serum samples were analyzed correspondingly. Punch biopsies were taken at the onset and at week 14 for CYP27A1 and CYP27B1 enzyme expression level analyses.
详细描述
The investigators investigated the ability of narrowband ultraviolet B (nbUVB) treatment in the maintenance of vitamin D levels achieved during the summer in Finland. The investigators randomized 37 subjects into groups of 17 and 18 subjects. The other group received 2 standard erythema doses (SED) nbUVB exposure every other week until week 24, and serum 25(OH)D levels were measured at the onset and at weeks 6, 14, 20, 26 and 30. The control group was not illuminated and serum samples were analyzed correspondingly. 6mm punch biopsies were taken at the onset and at week 14 for CYP27A1 and CYP27B1 enzyme expression level analyses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age over 18
- •Fitzpacker's skin type II-IV
排除标准
- •age under 18
- •diseases that inhibit vitamin D metabolism or absorption
- •Fitzpacker's skin type I
- •history of skin cancer
- •vitamin D substitution 1 month before baseline or during study
- •sun holidays 1 month before baseline or during study
结局指标
主要结局
25(OH)D level
时间窗: up to 30 weeks
Serum 25(OH)D levels were measured at the onset and at weeks 6, 14, 20, 26 and 30.
次要结局
- CYP27A1 and CYP27B1 enzyme expression levels(up to 14 weeks)