To Study the Risk Factors of Youth Coronary Heart Disease From Inflammatory Cytokines，Lifestyle and Familial Inheritance
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Whether inflammatory factors are differentially expressed in young patients with coronary heart disease
研究概览
简要总结
The incidence of coronary heart disease in young people is not uncommon and the investigators will explore the factors contributing to this outcome
详细描述
Through the multi-center clinical research conducted by several units in Nantong city, the risk factors and aggregation of the incidence of CHD among young people in nantong city were obtained, so as to fill in the blank of domestic multi-center research and reduce the incidence of CHD among young people.The investigators will conduct a long-term follow-up study on the young patients with CHD to screen the factors contributing to the poor prognosis of CHD in young patients.The investigators will fill this gap and intervene early to improve patients' quality of life and prolong their survival
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed coronary heart disease
- •Confirmed by coronary angiography
- •Diagnosed myocardial infarction
- •Willing to sign an inform consent
排除标准
- •Patients won't sign an inform consent or will not comply with the follow up.
结局指标
主要结局
Whether inflammatory factors are differentially expressed in young patients with coronary heart disease
时间窗: Until April 2024
The Investigators will analyze blood samples from the participants to see if there was a difference in the expression of inflammatory factors with high correlation compared with the control group by ELESA and High-throughput sequencing.
The effect of gene activity on youth morbidity
时间窗: Until April 2024
The investigators will use enrichment analysis to screen the target genes and sequence the participants.Whether the target gene was expressed at high levels in the participants.And the investigators will further analyze the target gene
Sedentary, high-fat diet, lack of exercise and other unhealthy lifestyle effects on young people
时间窗: Until April 2024
The researchers will retrospectively examine the participants' negative lifestyle habits, such as sedentary behavior, smoking, high-fat diet, and lack of exercise, in combination with their coronary angiography results
次要结局
未报告次要终点
研究者
Hongzhuan Sheng
Chief physician
Affiliated Hospital of Nantong University