ACTRN12624000400561尚未招募Unknown
Coronary Artery disease SCreening in young ADult relativEs of individuals with premature Myocardial Infarction (CASCADE-MI study)
适应症
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 入组人数
- 300
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 30 Years 至 55 Years（—）
- 性别
- All
入选标准
- •Apparently healthy first-degree relative aged 30 to 55 years of a patient with myocardial infarction at premature age (<55 years).
排除标准
- •Exclusion criteria for the apparently healthy relative will include:
- •History of cardiovascular disease (i.e., coronary artery disease, peripheral arterial disease, or cerebrovascular disease).
- •Already taking aspirin or statin.
- •History of iodinated contrast allergy/anaphylaxis.
- •Known renal impairment with estimated glomerular filtration rate <45 ml/min/1.73m2.
- •Unwilling or unable to provide informed consent.
- •Pregnant women.
- •Exclusion criteria for the index case (patient) will include the following diagnoses:
- •Non-atherosclerotic cause of myocardial infarction such as spontaneous coronary artery dissection, paradoxical venous thrombo-embolism, myocarditis, pericarditis, vasospasm, and Takotsubo cardiomyopathy.
- •Myocardial infarction with nonobstructive coronary arteries.
- •Probable or definite familial hypercholesterolaemia by the Dutch Lipid Clinic Network Criteria (score 6 or more).
- •Age <18 years.
研究者
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