NCT01141959已完成不适用
Blood Samples to Identify Biomarkers in Haploidentical Graft Recipients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Donor T-cell chimerism
研究概览
简要总结
The investigators are interested in identifying patient-specific factors related to donor chimerism in patients who receive nonmyeloablative hematopoietic stem cell transplants from haploidentical donors. We will look how patients' bodies break down and immediately respond to cyclophosphamide, fludarabine and mycophenolate mofetil.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Scheduled to receive nonmyeloablative conditioning which includes fludarabine
- •Scheduled to receive a haploidentical graft
- •Scheduled to receive postgrafting immunosuppression which includes oral mycophenolate mofetil (MMF) or enteric-coated mycophenolic acid
- •Age >18 years at the time of enrollment
排除标准
- •Diagnosed with an immunodeficiency disorder, including HIV
结局指标
主要结局
Donor T-cell chimerism
时间窗: Day 28 post-transplant
次要结局
- Exposure to cyclophosphamide, fludarabine, and mycophenolate mofetil and their breakdown products(1 week before through 3 weeks after transplant)
研究者
研究点 (1)
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