NCT00764829已完成不适用
Blood Samples to Evaluate Biomarkers of Donor Chimerism
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Donor T-cell chimerism
研究概览
简要总结
We are interested in patient-specific factors that may affect the balance of recipient cells and donor cells in patients who receive stem cell transplants. We will look at the way the patient's body breaks down two drugs, fludarabine and mycophenolate mofetil, and how these two drugs affect the patient's body.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with a hematologic disease or malignancy
- •Scheduled to receive nonablative conditioning with fludarabine and total body irradiation
- •Donor is well-matched by high resolution DNA techniques.
- •Scheduled to receive postgrafting immunosuppression of oral MMF (CellCept) and an oral calcineurin inhibitor.
- •Age >18 years at the time of enrollment.
- •Exclusion criteria:
- •Diagnosed with an immunodeficiency disorder
排除标准
- 未提供
结局指标
主要结局
Donor T-cell chimerism
时间窗: Day 28 post-transplant
次要结局
- Exposure to fludarabine and mycophenolate mofetil and their breakdown products.(Before and after transplant)
研究者
研究点 (1)
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