NCT00375778已完成不适用
Parkinson's Disease Evaluated by Positron Emission Tomography and the Effect of the NMDA Receptor Antagonist Memantine
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
研究概览
简要总结
Purpose of study: To investigate whether the NMDA antagonist Memantine has a substantial effect of brain metabolism in patients with Parkinson's disease (PD), using Positron Emission Tomography (PET).
Background: Disturbances in brain metabolism is thought to contribute to degeneration of neurons in brain of PD patients. Production of toxic oxygen radicals and presence of too much excitatory neurotransmitter (glutamate) due to over activity is involved. These factors can theoretically be alleviated by memantine.
Hypothesis: Memantine decreases metabolism in areas in PD brain known to be over-active. Decreases in cerebral blood flow and oxygen metabolism in these areas will be the consequence and this can be detected by PET.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parkinson's Disease (British Brain Bank Criteria)
- •Age 50-70y
排除标准
- •Tobacco use
- •Any serious medical conditions (Heart disease, kidney disease, liver disease, endocrinological disorders etc)
- •Metal implants contraindicating MR scan
- •Drug use affecting the central nervous system
- •Psychiatric disorders
- •Head trauma or any disorders of the head, skull or brain
- •Drug addiction or use of any kind of illegal substance affecting the central nervous system
- •Pregnancy
研究者
研究点 (2)
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