PET Imaging in Parkinson Disease Dementia
- Conditions
- Parkinson's Disease
- Registration Number
- NCT01052350
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
The purpose of this study is to use a brain imaging method called PIB PET to determine dementia subtypes in patients with Parkinson's disease. The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.
- Detailed Description
The purpose of this study is to use a brain imaging method called PIB PET to determine dementia subtypes in patients with Parkinson's disease. The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia. We will be including both PD and normal subjects in this study. This a long term study and we are considering including a total of 320 participants in this protocol.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 320
- PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.
- history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia
- severe systemic diseases
- inability to lie still for 90 minutes
- metallic implants, pacemakers, or any other contraindication to MRI
- refusal to consent to brain donation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
NeuroClinical Research Unit (NCRU), Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States