7.0T Magnetic Resonance Imaging Study of Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- The change in motor symptoms in PD patients.
研究概览
简要总结
This clinical trial study is conducted to detect the imaging characteristics of the patients with Parkinson's diseases (PD) by 7-Tesla (7T) magnetic resonance imaging (MRI).
详细描述
In this study,we explored the imaging characteristics of PD. First, with the advantage of 7T, we detect the slight changes of PD with short diseases history compared with the healthy. Second, we investigate the different imaging characteristics in subtypes of PD, finding the effective neuroimaging biomarkers to distinguish different subtypes of PD. Finally, we take long time follow-up to evaluate the correlation between the imaging changes and clinical score alteration in PD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •the patients with PD who was diagnosed by the experienced neurologist specializing in movement disorders
排除标准
- •the patients with brain disorders such as cerebrovascular disease, brain tumors, epilepsy, other neurodegenerative disease;
- •psychiatric disorders with impaired cognitive function;
- •contraindications to MRI.
结局指标
主要结局
The change in motor symptoms in PD patients.
时间窗: 5 year after the conduction of clinical trial
The patient's clinical state was evaluated according to the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) and H-Y scale. The former scale total score ranges from 0 to 199, with higher scores indicating more severe symptoms in patients. H-Y scale categorizes PD into five stages with higher stages indicate more severe symptoms. Comparison will be performed from examinations for case-control study versus for baseline and 5-year follow-up timepoints.
次要结局
- Functional connectivity alterations between individuals with different subtypes of PD and healthy subjects.(5 year after the conduction of clinical trial)
- Structural connectivity alterations between individuals with different subtypes of PD and healthy subjects.(5 year after the conduction of clinical trial)
- Clinical variables spectrum features linking to the motor symptoms and imaging spectrum features.(5 year after the conduction of clinical trial)
研究者
Xin Lou
Director and Clinical Professor
Chinese PLA General Hospital