Imaging the Motor System in Parkinson's Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson Disease
- Sponsor
- University of Delaware
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Functional MRI activity during a motor task
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
The study uses magnetic resonance imaging (MRI) to better understand changes in the brain underlying motor symptoms affecting upper and lower limbs in Parkinson's disease.
Detailed Description
There is a tremendous need to improve the understanding of the pathophysiology underlying motor symptoms in Parkinson's disease in order to optimize existing treatment options/develop new therapies. This study seeks to further the understanding of impaired movement in Parkinson's disease by examining brain changes and how these relate to changes in motor behavior. The study uses magnetic resonance imaging (MRI), a noninvasive imaging technique that does not include X-rays. MRI will assess brain activity in response to simple and coordinated movements of the upper and lower limbs that participants have to perform inside the MRI scanner. Motor and cognitive function outside the scanner using various clinical and behavioral tests will also be assessed. The study includes 1 visit to the University of Delaware.
Investigators
Roxana Burciu
Assistant Professor
University of Delaware
Eligibility Criteria
Inclusion Criteria
- •A clinical diagnosis of Parkinson's disease
- •No neurological disorders if interested in participating as a control participant
- •Must be capable of providing informed consent
- •Must be eligible to receive a brain MRI
Exclusion Criteria
- •A secondary movement disorder diagnosis in addition to Parkinson's disease
- •Medical conditions that may make one ineligible for receiving a brain MRI
- •Inability to provide informed consent
- •Control/healthy group: neurological disorders
- •Control/healthy group: cannot walk without an assistive device/mobility problems
Outcomes
Primary Outcomes
Functional MRI activity during a motor task
Time Frame: Baseline
Functional MRI activity during isolated/coordinated movements of the upper and lower limbs
Secondary Outcomes
- Five Times Sit to Stand(Baseline)
- The Modified Clinical Test of Sensory Interaction and Balance (mCTSIB)(Baseline)
- Purdue Pegboard Test(Baseline)
- Parkinson's Disease Questionnaire (PDQ-39)(Baseline)
- Kinesia One(Baseline)
- Movement Disorder Society Unified Parkinson's Disease Rating Scale(Baseline)
- Schwab and England Activities of Daily Living Scale(Baseline)
- Timed Up and Go(Baseline)
- 360-Degree Turn Test(Baseline)
- 2-Minute Walking Test(Baseline.)
- Brief Test of Attention(Baseline)
- University of Pennsylvania Smell Identification Test(Baseline)
- Grooved Pegboard(Baseline)
- Montreal Cognitive Assessment Test(Baseline)
- Beck Depression Inventory II(Baseline)
- Rapid Eye Movement Behavior Disorder Questionnaire(Baseline)
- Epworth Sleepiness Scale(Baseline)