NCT01237210已完成不适用
Magnetic Resonance Spectroscopy of Parkinson's Disease at 7 Tesla
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- Magnetic resonance spectroscopy (MRS)
研究概览
简要总结
This study is looking for healthy controls and patients with Parkinson's (PD) to perform an MR scan.
- The neurochemical profile of the SN of patients with PD as measured by high field MRS will differ from that of healthy controls, in that glutathione will be lower due to oxidative stress, lactate will be higher due to mitochondrial dysfunction, the gliosis markers myo-inositol and glutamine will be higher due to inflammation (glial activation) and N-acetylaspartate and glutamate will be lower due to neuronal loss/damage.
- There will be a relationship between neurochemical changes and disease severity.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Parkinson's disease Group
- •Parkinson's disease (clinical diagnostic criteria)
- •Age 45-75 years inclusive
- •Able to safely undergo MRI scanning
- •Absence of diabetes and smoking
- •Capable of giving informed consent
- •Healthy Control Group
- •Age 45-75 years inclusive
- •Able to safely undergo MRI scanning
- •Absence of diabetes and smoking
- •Capable of giving informed consent
排除标准
- •Parkinson's disease Group
- •Dementia (clinically determined by PI Dr. Tuite)
- •Diagnosis of atypical parkinsonism
- •Inability to safely undergo MRI scanning
- •Inability to give informed consent
- •Unstable medical conditions
- •Present smoker
- •Diabetic (on oral or injectable medications for diabetes)
- •Taken coenzyme Q10 or Vitamin E in the 2 weeks prior to the scan
- •Does not meet age criteria
- •Healthy Control Group
- •Has a 1st degree relative with PD
- •Dementia (clinically determined by PI Dr. Tuite)
- •Inability to safely undergo MRI scanning
- •Inability to give informed consent
- •Unstable medical conditions
- •Present smoker
- •Diabetic (on oral or injectable medications for diabetes)
- •Taken coenzyme Q10 or Vitamin E in the 2 weeks prior to the scan
- •Does not meet age criteria
结局指标
主要结局
Magnetic resonance spectroscopy (MRS)
时间窗: Baseline
We will utilize optimized magnetic resonance spectroscopy (MRS) methodology to address theories of pathogenesis of Parkinson's disease (PD) by quantifying glutathione (GSH), lactate, glutamine and myo-inositol levels of the unilateral substantia nigra (SN) of healthy volunteers and patients with PD.
次要结局
未报告次要终点
研究者
研究点 (1)
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