Evaluation of Early Disease in Familial Dilated Cardiomyopathy

Phase 3

Completed

• Conditions: Familial dilated cardiomyopathy; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12605000204640
• Lead Sponsor: St Vincent's Hospital, Darlinghurst

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-08-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

Positive family history, absence of heart failure symptoms, increased left ventricular end-diastolic diameter (>112% predicted) with or without mild impairment of systolic function (ejection fraction 40-55%).

Exclusion Criteria

Chronic airflow limitation with >20% reversibility, heart rate less than 50 beats per minute, blood pressure <80/50mmHg.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in left ventricular end-systolic and/or end-diastolic dimensions after 6 months of intervention when compared with baseline measurements.[At baseline and after 6 months of intervention.]

Secondary Outcome Measures

Name	Time	Method
Clinical evidence of disease progression, with heart failure symptoms and/or worsening of left ventricular contractile function.[After 6 months of intervention when compared with baseline measurements.]