Study the preventive effect of Carvedilol therapy against Adriamycin-induced acute cardiotoxicity in breast cancer patients by measurement of myocardial deformation index

Phase 2

• Conditions: Condition 1: breast cancer. Condition 2: heart failure.; Breast, unspecified; Congestive heart failure

• Registration Number: IRCT2013093012924N1
• Lead Sponsor: Vice chancellor for research, Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

breast cancer patients who are candidate for chemotherapy with adriamycin.
Exclusion criteria:
documented heart disease; history of radiation or chemotherapy for cancer; metastatic disease; atrial fibrillation; BMI more than 30; creatinin more than 2; EF less than 30%; pulmonary congestion; beta blocker contraindications; insulin dependent diabetes mellitus; major depression; suicide attempt; pregnancy

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Strain rate. Timepoint: before intervention, at the middle of intervention, after intervention. Method of measurement: echocardiography.

Secondary Outcome Measures

Name	Time	Method
Complications of carvedilol. Timepoint: during intervention. Method of measurement: by taking history.