Community Exercise Treating Effect on Cardiopulmonary Disease Patients

Not Applicable

Recruiting

• Conditions: Coronary Heart Disease (CHD); Heart Failure; Cardiomyopathy; COPD; Bronchial Asthma; Thoracic Tumors; Respiratory Failure; Cardiopulmonary Diseases

• Registration Number: NCT07154355
• Lead Sponsor: Guangdong Provincial People's Hospital

Brief Summary

The goal of this clinical trial is to learn if community-based exercise training can benefit patients aged 18 to 85 with diminished cardiovascular and pulmonary function. The main aim of this study is:

• Establish a community or home-based fitness training program for patients with cardiopulmonary insufficiency to improve adherence, safety, and efficacy while alleviating the burden on both patients and society.

Researchers will compare community-based exercise training to non-exercise training to see if community-based exercise training works to improve cardiovascular and pulmonary function.

Participants will:

* Engage in community or home exercise training for 40-60 minutes, five times weekly, during a duration of eight weeks. Exercise modalities are primarily determined by the patients' individual preferences and habits, such as brisk walking, running, swimming, cycling, and hiking.

* Adjust the exercise intensity according to their cardiopulmonary exercise test and the person's perceived exertion level.

* Utilize fitness bracelets or watches to document statistics during workouts and submit them to the experimenter weekly, covering the five days of exercise within that week.

* refrain from making any dietary modifications throughout the trial.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-01
• Study First Submitted: 2025-01-25
• Study Start: 2025-01-30
• Study First Submitted QC: 2025-08-26
• Last Update Submitted: 2025-08-26
• Study First Posted: 2025-09-04
• Last Update Posted: 2025-09-04
• Primary Completion: 2029-12
• Study Completion: 2030-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Patients aged 18 to 85 with abnormal pulmonary or cardiovascular function.
2. Individuals who have completed a medical screening form to confirm they are free from illnesses and prescription medications that could impair their ability to complete the required testing and fitness training.
3. Participants who did not engage in structured, systematic moderate-to-intense strength or endurance training during the study period (specifically, not within the previous year).
4. At the onset of the trial, participants were physically active but had never participated in formal exercise more than twice a week.

Exclusion Criteria

1. Patients with neuromuscular or skeletal disorders, or systemic diseases such as diabetes, cancer, or heart disease.
2. Individuals using medications known to affect health or the interpretation of study results.
3. Participants who have engaged in organized, systematic endurance or strength training of moderate to high intensity within the past year.
4. Patients who decline to participate in the study.
5. Other medical conditions or states that render exercise training inappropriate.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
exercise capacity	at enrollment and week 8	Anaerobic Threshold (AT, mmol/L) is a key physiological parameter in cardiopulmonary exercise testing (CPET), representing the transition point from predominantly aerobic to anaerobic metabolism during incremental exercise. It is determined by measuring blood lactate concentration through serial blood sampling and plotting the lactate-exercise intensity curve.
life quality	at enrollment and week 8	The Short Form-36 Health Survey (SF-36) was administered, with scores ranging from 0 to 100 across its eight subscales. Higher scores reflect superior health-related quality of life (HRQoL).

Secondary Outcome Measures

Name	Time	Method
Leg strength	at enrollment and week 8	The Nottingham strength test device is used to assess lower limb muscle strength, with a focus on measuring leg extensor power. By calculating the ratio of power output to body weight (power/weight), it indirectly reflects muscle functional status.
Other exercise capacity outcome	at enrollment and week 8	Ventilation/carbon dioxide (VE/VCO₂, mL/(kg·min)) slope, a key parameter for assessing ventilatory efficiency in cardiopulmonary exercise testing (CPET), is defined as the linear regression slope of minute ventilation (VE) against carbon dioxide output (VCO₂), reflecting the volume of ventilation required to eliminate 1 liter of CO₂ during exercise.
cardiac function	at enrollment and week 8	Left ventricular ejection fraction (LVEF, %), measured by Doppler echocardiography, is used to assess left ventricular systolic function, representing the percentage of blood pumped out per heartbeat relative to the left ventricular end-diastolic volume.
Blood indices	at enrollment and week 8	Plasma interleukin-6 (IL-6, pg/mL) levels, a multifunctional proinflammatory cytokine, are used to assess systemic inflammation levels

Trial Locations

Locations (1)

Department of Rehabilitation Medicine Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences); 🇨🇳 Guangzhou, Guangdong, China