Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- relationship between cerebral perfusion pressure variability and sepsis-associated encephalopathy
研究概览
简要总结
The purpose of the study is to evaluate whether variability of CPP (cerebral perfusion pressure) is related to sepsis-associated encephalopathy and outcomes of patients with sepsis.
详细描述
Encephalopathy is a common complication of sepsis, impaired cerebrovascular autoregulation (AR) in patients with sepsis is considered related to Sepsis-associated encephalopathy (SAE). As AR is important in stabilizing the cerebral perfusion pressure, whether greater variability of CPP is related to SAE and mortality or not remains unclear. We conduct this study to evaluate the relationship between them.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinical symptoms of sepsis, severe sepsis and septic shock
- •age over 18 years
排除标准
- •preexisting Neurological diseases
- •traumatic brain injury
- •intracranial infectious disease
- •severe hepatic or renal dysfunction
- •ICU discharge Within 72 hours
- •pregnancy
结局指标
主要结局
relationship between cerebral perfusion pressure variability and sepsis-associated encephalopathy
时间窗: cerebral perfusion pressure is assessed up to 72 hours
To estimate CPP noninvasively, we will monitor the middle cerebral artery flow velocity of patients with sepsis using transcranial Doppler ultrasound in the first 72h of their enrollment. Diagnosis of a SAE was performed using the confusion assessment method for ICU(CAM-ICU).
次要结局
- Time of hospital stay(All the participants will be followed up until discharge or death, assessed up to 24 months)
- 90-day mortality rate(All the participants will be followed up until 90 days after their enrollment or death)
- Duration of mechanical ventilation(All the participants will be followed up until discharge or death, assessed up to 24 months)
- Time of ICU stay(All the participants will be followed up until discharge or death, assessed up to 24 months)
- 2-year quality of life of survivors(All the participants will be followed up until 2 year after their enrollment or death)
- 1-year mortality rate(All the participants will be followed up until 1 year after their enrollment or death)
- 2-year mortality rate(All the participants will be followed up until 2 years after their enrollment or death)
- 1-year quality of life of survivors(All the participants will be followed up until 1 year after their enrollment or death)
研究者
Kang Yan
Director of Intensive Care Unit
West China Hospital