Parameters of Cerebral Perfusion

Not Applicable

Completed

• Conditions: Cerebral Perfusion; Cerebral Oxygenation; Cardiopulmonary Bypass

• Registration Number: NCT02806492
• Lead Sponsor: UMC Utrecht

Brief Summary

The purpose of this study is to determine whether cerebral blood flow and cerebral tissue oxygenation is most dependent on cardiac output or on mean arterial pressure in patients undergoing cardiac surgery with the use of cardiopulmonary bypass.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01
• Study First Submitted: 2016-06-15
• Study First Submitted QC: 2016-06-15
• Study First Posted: 2016-06-20
• Primary Completion: 2017-03-17
• Study Completion: 2017-03-17
• Status Verified: 2017-06
• Last Update Submitted: 2017-06-07
• Last Update Posted: 2017-06-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Undergoing cardiopulmonary bypass for CABG a
• having an appropriate temporal bone window for reliable TCD monitoring
• needing pharmacological intervention because of hypotension before going on CPB.

Exclusion Criteria

• requiring hypothermia during surgery
• requiring emergency surgery
• contraindication for phenylephrine,
• having known brain pathology (e.g. Cerebral Vascular Accident (CVA) or increased intracranial pressure
• having a history of severe carotid artery stenosis.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
regional cerebral oxygen saturation	During surgery
mean velocity of blood flow of the middle cerebral artery	During surgery

Trial Locations

Locations (1)

UMC Utrecht; 🇳🇱 Utrecht, Netherlands