Cerebral Oxygenation and Circulatory Parameters During Pressure Controlled vs. Volume Targeted Mechanical Ventilation in the Extremely Preterm Infants With Respiratory Distress Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Distress Syndrome, Newborn
- Sponsor
- Poznan University of Medical Sciences
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Stroke volume variation (SVV)
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of the study was to assess the effect of volume targeted vs. pressure-controlled mechanical ventilation (MV) on circulatory parameters and cerebral oxygenation in the extremely preterm infants.
Detailed Description
Prospective, cross-over trial enrolling neonates \<28 weeks' gestation requiring MV. Patients were ventilated for 3 hours with pressure controlled assist-control (PC-AC) mode, followed by 3-hours of volume guarantee assist-control ventilation (VG-AC). Continuous monitoring was carried out using pulse oximetry (oxygen saturation - SpO2 and heart rate - HR), near-infrared spectroscopy (cerebral oxygenation - StO2) and electrical cardiometry (circulatory parameters).
Investigators
Eligibility Criteria
Inclusion Criteria
- •premature infants born \<28 weeks of gestation
- •respiratory failure in the course of respiratory distress syndrome requiring mechanical ventilation
- •stable condition with pH (acidity of blood)\> 7.2 and pCO2 (carbon dioxide partial pressure) \<60 mmHg in the blood gas analysis
- •no identified genetic syndromes and serious congenital malformations
Exclusion Criteria
- •lack of written consent of patients' parents
Outcomes
Primary Outcomes
Stroke volume variation (SVV)
Time Frame: 6 hours
Stroke volume variation (SVV) monitored with electrical cardiometry \[percent\]
Index of contractility
Time Frame: 6 hours
Index of contractility (ICON) monitored with electrical cardiometry
Stroke volume
Time Frame: 6 hours
Stroke volume (SV) monitored with electrical cardiometry \[ml\]
Cardiac output
Time Frame: 6 hours
Cardiac output (CO) monitored with electrical cardiometry \[L/min\]
Stroke index
Time Frame: 6 hours
Stroke index (SI) monitored with electrical cardiometry \[ml/m2\]
Cardiac index
Time Frame: 6 hours
Cardiac index (CI) monitored with electrical cardiometry \[L/min/m2\]
StO2
Time Frame: 6 hours
Cerebral oxygenation measured using near-infrared spectroscopy \[percent\]