Cardiac Output and Duplex Sonography in Carotid Endarterectomy
- Conditions
- Carotid Stenosis
- Registration Number
- NCT02230358
- Lead Sponsor
- Medical University Innsbruck
- Brief Summary
The aim of this study is to investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine.
- Detailed Description
The investigators will investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine.
For this purpose patients with the need of a carotid endarterectomy (CEA) will be included and randomized either to the regional anesthesia (RA) or the general anesthesia (GA) group until a patient number of 45 in each group is achieved.
The cardiac output and cerebral blood-flow via trans-cranial Doppler (TCD) will be measured at 6 time points:
* T0 Baseline (after insertion of an arterial line)
* T1 After induction of anesthesia, but before surgical start
* T2 Two minutes after clamping the carotid artery
* T3 Two minutes after shunt insertation of the carotid artery
* T4 After reperfusion
* T5 After completion of the skin suture
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
- Age >= 18 years
- Elective carotid endarterectomy
- Signed informed consent
- Age under 18 years
- Missing signed informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Influence of anesthetic technique on cardiac output during carotid endarterectomy. Baseline to induction of anesthesia and up to 1 hour after admission to the intermediate care unit Number of participants: 90 patients
Unit of measure: Cardiac index (l/m2)
Cardiac output will be measured and compared at the following time points:
* T0 Baseline (after insertion of an arterial line)
* T1 After induction of anesthesia, but before surgical start
* T2 Two minutes after clamping the carotid artery
* T3 Two minutes after shunt insertation of the carotid artery
* T4 After reperfusion
* T5 After completion of the skin suture
- Secondary Outcome Measures
Name Time Method Influence of anesthetic technique on trans-cranial doppler flow during carotid endarterectomy. Change of cardiac output from Baseline to induction of anesthesia and up to 1 hour after admission to the intermediate care unit Cerebral blood flow will be measured via trans-cranial Doppler (TCD) and compared at the following time points:
* T0 Baseline (after insertion of an arterial line)
* T1 After induction of anesthesia, but before surgical start
* T2 Two minutes after clamping the carotid artery
* T3 Two minutes after shunt insertation of the carotid artery
* T4 After reperfusion
* T5 After completion of the skin suture
Related Research Topics
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Trial Locations
- Locations (1)
Medical University Innsbruck
🇦🇹Innsbruck, Tirol, Austria
Medical University Innsbruck🇦🇹Innsbruck, Tirol, Austria