Cardiac Output and Cerebral Blood-flow During Carotid Endarterectomy in Regional vs. General Anesthesia. A Prospective Randomized Controlled Single Center Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Carotid Stenosis
- Sponsor
- Medical University Innsbruck
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Influence of anesthetic technique on cardiac output during carotid endarterectomy.
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The aim of this study is to investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine.
Detailed Description
The investigators will investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine. For this purpose patients with the need of a carotid endarterectomy (CEA) will be included and randomized either to the regional anesthesia (RA) or the general anesthesia (GA) group until a patient number of 45 in each group is achieved. The cardiac output and cerebral blood-flow via trans-cranial Doppler (TCD) will be measured at 6 time points: * T0 Baseline (after insertion of an arterial line) * T1 After induction of anesthesia, but before surgical start * T2 Two minutes after clamping the carotid artery * T3 Two minutes after shunt insertation of the carotid artery * T4 After reperfusion * T5 After completion of the skin suture
Investigators
Priv.Doz. Dr. Corinna Velik-Salchner
Priv.-Doz. Dr.
Medical University Innsbruck
Eligibility Criteria
Inclusion Criteria
- •Age \>= 18 years
- •Elective carotid endarterectomy
- •Signed informed consent
Exclusion Criteria
- •Age under 18 years
- •Missing signed informed consent
Outcomes
Primary Outcomes
Influence of anesthetic technique on cardiac output during carotid endarterectomy.
Time Frame: Baseline to induction of anesthesia and up to 1 hour after admission to the intermediate care unit
Number of participants: 90 patients Unit of measure: Cardiac index (l/m2) Cardiac output will be measured and compared at the following time points: * T0 Baseline (after insertion of an arterial line) * T1 After induction of anesthesia, but before surgical start * T2 Two minutes after clamping the carotid artery * T3 Two minutes after shunt insertation of the carotid artery * T4 After reperfusion * T5 After completion of the skin suture
Secondary Outcomes
- Influence of anesthetic technique on trans-cranial doppler flow during carotid endarterectomy.(Change of cardiac output from Baseline to induction of anesthesia and up to 1 hour after admission to the intermediate care unit)