Phospholipid and energy metabolism in the healthy aging brai

Completed

• Conditions: gezonde veroudering; aging; healthy aging

• Registration Number: NL-OMON40713
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

aged 60 years or older

Exclusion Criteria

Significant neurological or psychiatric disease
MRI contra-indications
Use within two months prior to visit of:
- omega-3 fatty acid containing supplements
- oily fish (when consumed more than twice a week)
Use within one month prior to visit of:
- vitamins B, C and/ or E > 200% RDA

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Outcome measures are relative metabolite levels of the phosphomonoesters<br /><br>phosphocholine and phosphoethanolamine, and of the phosphodiesters<br /><br>glycerophosphocholine and glycerophosphoethanolamine to total phosphorus<br /><br>signal, the ratio of phosphomonoesters to phosphodiesters, and relative<br /><br>metabolite levels of alpha, beta and gamma adenosinetriphosphate,<br /><br>phosphocreatine, inorganic phosphate and nicotinamide adenine dinucleotide to<br /><br>total phosphorus signal. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Blood parameters: Fatty acid profile in erythrocyte membrane, fatty acid<br /><br>profile in plasma, Choline, Homocysteine, Vitamin E, Uridine, and optionally,<br /><br>plasma phospholipids.</p><br>