Kinetic Defects in Lipoprotein Metabolism in Patients with Renal Failure

Not Applicable

Completed

• Conditions: Chronic renal disease; Lipoprotein metabolism; Renal and Urogenital - Other renal and urogenital disorders

• Registration Number: ACTRN12605000726651
• Lead Sponsor: Cardiovascular Lipid Research Grant Pfizer

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-11-11
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Non-diabetic CRF (GFR 40-60 ml/min) and 20 age, sex and weight matched healthy controls.

Exclusion Criteria

Type 1 or 2 Diabetes mellitus; Nephrotic Syndrome; Renal Replacement Therapy; BMI > 35 kg/m2; On lipid-modifying therapy; Alcohol consumption > 3 standard drinks / day; Liver disease; Primary dyslipidaemia (familial hypercholesterolaemia or familial combined hyperlipidaemia) or non-uraemia related secondary dyslipidaemia; Untreated thyroid disease; Significant psychiatric disorder; Cyclical hormone therapy in females.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. ApoB and apoAI metabolism [Following recruitment];2. Insulin sensitivity.[Following recruitment]