ChanGes In Right ventricular volumes And Function Following diurEtic Treatment In Pulmonary arterial hypertension patients with decompensated right heart failure (GIRAFFE) - Changes in right ventricular volumes and function

Vrije Universiteit0 个研究点目标入组 34 人开始时间: 待定最近更新: 2024年8月12日

适应症

试验速览

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•- Diagnosis of idiopathic PAH, hereditary PAH, drug- and toxins induced PAH or chronic thrombo-embolic PH (CTEPH), according to ESC/ERS pulmonary hypertension guidelines (15)
•- Symptoms of decompensated right heart failure (ankle edema, ascites, weight gain) based on the assessment and the evaluation of the pulmonologist for which an up-titration of the diuretics is indicated
•- Age >=18 and <=80 years
•- Able to understand and willing to sign the Informed Consent Form

•- Pregnant subjects
•- Claustrophobia
•- Inability to provide informed consent
•- Change in PAH specific therapy during or the 3 months before the up-titration of diuretics
•- Change in (dose) of any other medication.
•- One or more of the following co-morbidities:, uncontrolled systemic hypertension (>140/90 mmHg) , renal failure (eGFR <30), recent diagnosis of pulmonary embolism (within 6 months).
•- Contraindication for CMR imaging:
•o Claustrophobia
•o Implanted cardiac defibrillator or pacemaker
•o Cochlear implant
•- PH of any cause other than permitted in the entry criteria
•- Known history of noncompliance considering therapies

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