NL-OMON44204
Completed
N/A
ChanGes In Right ventricular volumes And Function Following diurEtic Treatment In Pulmonary arterial hypertension patients with decompensated right heart failure (GIRAFFE) - Changes in right ventricular volumes and function
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- pulmonary hypertension
- Sponsor
- Vrije Universiteit
- Enrollment
- 34
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Diagnosis of idiopathic PAH, hereditary PAH, drug\- and toxins induced PAH or chronic thrombo\-embolic PH (CTEPH), according to ESC/ERS pulmonary hypertension guidelines (15\)
- •\- Symptoms of decompensated right heart failure (ankle edema, ascites, weight gain) based on the assessment and the evaluation of the pulmonologist for which an up\-titration of the diuretics is indicated
- •\- Age \>\=18 and \<\=80 years
- •\- Able to understand and willing to sign the Informed Consent Form
Exclusion Criteria
- •\- Pregnant subjects
- •\- Claustrophobia
- •\- Inability to provide informed consent
- •\- Change in PAH specific therapy during or the 3 months before the up\-titration of diuretics
- •\- Change in (dose) of any other medication.
- •\- One or more of the following co\-morbidities:, uncontrolled systemic hypertension (\>140/90 mmHg) , renal failure (eGFR \<30\), recent diagnosis of pulmonary embolism (within 6 months).
- •\- Contraindication for CMR imaging:
- •o Claustrophobia
- •o Implanted cardiac defibrillator or pacemaker
- •o Cochlear implant
Outcomes
Primary Outcomes
Not specified
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