NL-OMON51476
Recruiting
N/A
changed right heart volumes and function following diuretic withdrawal in pulmonary hypertension - Diuretic effect on the right heart
Amsterdam UMC0 sites17 target enrollmentTBD
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Amsterdam UMC
- Enrollment
- 17
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Diagnosed with idiopathic PAH, hereditary PAH, drug\- and toxins induced PAH
- •according to ESC/ERS pulmonary hypertension guidelines
- •\- Minimal dosage of 40mg furosemide or 1mg bumetanide a day
- •\- NYHA classification II
- •\- Age \>\=18 and \<\=80 years
- •\- Able to understand and willing to sign the Informed Consent Form
Exclusion Criteria
- •\- Pregnant subjects
- •\- Inability to provide informed consent
- •\- Change in PAH specific therapy within 3 months before diuretic withdrawal
- •\- Change in (dose of) any other medication
- •\- Hospitalized for acute decompensation within one year before diuretic
- •\- One or more of the following co\-morbidities:, uncontrolled systemic
- •hypertension (\>140/90
- •mmHg) , renal failure (eGFR \<30\), recent diagnosis of pulmonary
- •embolism (within 6 months).
- •\- Contraindication for CMR imaging:
Outcomes
Primary Outcomes
Not specified
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