NL-OMON51476RecruitingNot Applicable
changed right heart volumes and function following diuretic withdrawal in pulmonary hypertension - Diuretic effect on the right heart
Amsterdam UMC0 sites17 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 17
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •- Diagnosed with idiopathic PAH, hereditary PAH, drug- and toxins induced PAH
- •according to ESC/ERS pulmonary hypertension guidelines
- •- Minimal dosage of 40mg furosemide or 1mg bumetanide a day
- •- NYHA classification II
- •- Age >=18 and <=80 years
- •- Able to understand and willing to sign the Informed Consent Form
Exclusion Criteria
- •- Pregnant subjects
- •- Inability to provide informed consent
- •- Change in PAH specific therapy within 3 months before diuretic withdrawal
- •- Change in (dose of) any other medication
- •- Hospitalized for acute decompensation within one year before diuretic
- •- One or more of the following co-morbidities:, uncontrolled systemic
- •hypertension (>140/90
- •mmHg) , renal failure (eGFR <30), recent diagnosis of pulmonary
- •embolism (within 6 months).
- •- Contraindication for CMR imaging:
- •o Claustrophobia
- •o Implanted cardiac defibrillator or pacemaker
- •o Cochlear implant
- •- PH of any cause other than permitted in the entry criteria
- •- Known history of noncompliance considering therapies
Investigators
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