Effect of Dual Task Training on Balance, Gait, Cognition and Neurotrophic Factors in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Balance-Postural Stability
研究概览
简要总结
The aim of study is to analyze the effects of dual task training on balance, gait, cognition and neurotrophic factors in Parkinson's disease.
详细描述
20 patients diagnosed with Parkinson's disease will be randomly assigned to either intervention or control group. And 10 healty subjects will be included to study in order to determine the reference values.The intervention group will be recieved cognitive and motor dual task training consisting of balance and walking activities 3 days a week for 8 weeks. Control group will be recieved same balance and walking activities in single task condition 3 days a week for 8 weeks. In order to evaluate the effects of the training, evaluations will be performed before and after the training period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •at least 40 years of age
- •neurologist-diagnosed Parkinson's Disease
- •Hoehn & Yahr (H&Y) stages 1 to 3
- •24 or more mini mental status examination score.
排除标准
- •other neurologic disorder
- •cardiovascular, inflammatory,vestibular or musculoskeletal problems that could prevent them to participate in an exercise program
- •had deep brain stimulation history
- •visual, auditory, orientational problems that could affect study results
结局指标
主要结局
Balance-Postural Stability
时间窗: 8 weeks
Postural Stability will be evaluated with Biodex Biosway Portable Balance System (Biodex Medical Systems Inc., Shirley, New York).. Postural Stability test will performed on both feet and on the left and right foot separately. Total stability index score will obtained as the test result.
Montreal Cognitive Assessment (MoCA)
时间窗: 8 weeks
Montreal Cognitive Assessment (MoCA) will be used in order to evaluate cognition. It assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation.It' score ranged from 0 to 30 and higher points indicates better cognitive outcomes.
Balance- Limits of Stability
时间窗: 8 weeks
Limits of Stability will be evaluated with Biodex Biosway Portable Balance System (Biodex Medical Systems Inc., Shirley, New York). Limits of Stability test assesses how much the center of gravity is displaced on the support surface without losing balance during the standing position. Total direction control score will obtained as the test result.
Balance- Modified Sensory Organization Tests
时间窗: 8 weeks
Modified Sensory Organization Tests will be evaluated Biodex Biosway Portable Balance System (Biodex Medical Systems Inc., Shirley, New York). MSOT assesses the effects of somatosensory, visual and vestibular senses on postural control during the standing position. It evaluates the sensory component of balance in two different visual conditions and on two different support surfaces; condition 1: eyes open-firm surface, condition 2: eyes closed-firm surface, condition 3: eyes open-foam surface and condition 4: eyes closed-foam surface. Stability index scores will obtained as the test result.
Gait Speed
时间窗: 8 weeks
Gait speed will be evaluated by using the BTS-G Walk system and recorded as m/min. It is a wireless system positioned on L5 vertebrae of the spine. It allows a functional objective gait analysis to be performed.
Cadence
时间窗: 8 weeks
Cadence will be evaluated by using the BTS-G Walk system and recorded as strides/min. It is a wireless system positioned on L5 vertebrae of the spine. It allows a functional objective gait analysis to be performed.
Stride width
时间窗: 8 weeks
Stride width will be evaluated by using the BTS-G Walk system and recorded as meters. It is a wireless system positioned on L5 vertebrae of the spine. It allows a functional objective gait analysis to be performed.
Stride length
时间窗: 8 weeks
Stride length will be evaluated by using the BTS-G Walk system and recorded as meters. It is a wireless system positioned on L5 vertebrae of the spine. It allows a functional objective gait analysis to be performed.
Change in insulin like growth factor 1 (IGF-1) levels of serum
时间窗: 8 weeks
Insulin like growth factor 1 (IGF-1) levels of serum will be measured by using sandwich enzyme-linked immunosorbent assay (ELISA) kit.
Change in brain derived neurotrophic factor (BDNF) levels of serum
时间窗: 8 weeks
Brain derived neurotrophic factor (BDNF) levels of serum will be measured by using sandwich enzyme-linked immunosorbent assay (ELISA) kit.
Change in vascular endothelial growth factor (VEGF) levels of serum
时间窗: 8 weeks
Vascular endothelial growth factor (VEGF) levels of serum will be measured by using sandwich enzyme-linked immunosorbent assay (ELISA) kit.
次要结局
- Stroop Test(8 weeks)
- One-legged Stance Test(8 weeks)
- Timed Up and Go (TUG) test(8 weeks)
- Activities-Specific Balance Confidence (ABC) Scale(8 weeks)
- Trail Making Test (TMT) Part A and B(8 weeks)
- Unified Parkinson's Disease Rating Scale (UPDRS)(8 weeks)
- Berg Balance Scale (BBS)(8 weeks)
- Short-Form 8-Item Parkinson's Disease Questionnaire (PDQ-8)(8 weeks)
- Hoehn and Yahr Scale for level of physical disability in Parkinson's disease.(8 weeks)
研究者
Çağrı Gülşen
Principal Investigator
Gazi University