Phenotypic and Epigenetic "Trained Immunity" Characteristics of Hematopoietic Stem and Progenitor Cells in Patients With Established Atherosclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Phenotypical characteristics of HSPC's
研究概览
简要总结
An observational pilot proof-of-principle study. 15 patients with significant coronary artery disease and 15 matched controls. To investigate whether long-term activation of the innate immune system, named 'trained innate immunity', occurs at the level of the bone marrow progenitor cells in patients with significant coronary artery disease and whether this correlates with the proinflammatory phenotype of monocytes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 and ≤75 years
- •With or without significant coronary artery disease on CCTA
- •Written informed consent
排除标准
- •Chronic infections
- •Diabetes mellitus
- •Medical history of any disease associated with immune deficiency
- •Clinically significant infections within 3 months prior to study entry
- •Recent hospital admission or surgery with general anaesthesia
- •Known chronic kidney or liver disease
- •Previous vaccination within 3 months prior to study entry
- •Inability to personally provide written informed consent
- •Inability to undergo PET-CT scanning
- •Chronic use of anti-inflammatory drugs such as NSAIDs
- •History of haematological malignant disease
- •Documented bleeding diathesis or thrombocytopenia
- •Pregnancy
结局指标
主要结局
Phenotypical characteristics of HSPC's
时间窗: Study day 2 for patients
Phenotypical characteristics of HSPC's populations of patients with and without significant coronary artery disease by flowcytometry in percentages.
Cytokine response of circulating monocytes
时间窗: Study day 2 for patients
Cytokine response of monocytes of patients with and without significant coronary artery disease after 24 hour stimulation with several stimuli measured in cytokine levels.
次要结局
未报告次要终点