Modulation of reconsolidation-associated memory network dynamics by a pharmacological intervention.
Not Applicable
- Conditions
- Basic science study investigating stress effects on behavioral and neural correlates of memory processes with potential implications for stress-associated disorders such as PTSD and depression.
- Registration Number
- DRKS00029365
- Lead Sponsor
- niversitätsklinikum Eppendorf - Sonderforschungsbereich 936 - Multi-Site Communication in the Brain
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 68
Inclusion Criteria
very good knowledge of German
- Right-handed
Exclusion Criteria
- Pregnancy
- Psychology studies
- smoker
- hormonal contraceptives (e.g. pill, ring, patches etc.)
- metal on/in the body (e.g. stents, copper coil, piercings that cannot be removed)
- acute illnesses and/or medication
- history of neurological or mental disorders
- participated in a study in the last 2 months in which active substances had to be taken
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To investigate the influence of physiological stress mediators after memory reactivation on memory performance as well as the brain processes involved in it 24 h later.<br><br>Memory performance will be assessed on the third day of the study, 24 h after the pharmacological intervention, using computerized tests. In these tests, old words (learned on day 1) and new words are presented. Subjects must first indicate whether the word shown is old or new, and then indicate which picture belongs to that word.
- Secondary Outcome Measures
Name Time Method Knowledge of the influence of stress on reconsolidation and related changes in neural correlates.