A Three-Arm Comparative Trial for the Treatment of MAC Bacteremia in AIDS: A Clarithromycin/Ethambutol Regimen Containing Rifabutin (450 Mg) or Rifabutin (300 Mg) or Placebo
- Conditions
- Mycobacterium Avium-Intracellulare InfectionHIV Infections
- Registration Number
- NCT00002101
- Lead Sponsor
- Pharmacia
- Brief Summary
To compare the efficacy of clarithromycin/ethambutol with placebo or with rifabutin at two different doses in reducing colony-forming units (CFUs) by 2 or more logarithms in patients with Mycobacterium avium Complex bacteremia and maintaining this response until 16 weeks post-randomization. To assess survival and comparative tolerability among the three treatment regimens.
- Detailed Description
Patients are randomized to receive clarithromycin and ethambutol plus either placebo or rifabutin at one of two doses. Treatment continues indefinitely. AS PER AMENDMENT 04/19/94: Doses of rifabutin have been lowered.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 450
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (43)
McDowell Clinic
๐บ๐ธPhoenix, Arizona, United States
Maricopa Med Research Foundation
๐บ๐ธPhoenix, Arizona, United States
Bay Harbor Hosp
๐บ๐ธHarbor City, California, United States
Ctr for Special Immunology
๐บ๐ธMiami Beach, Florida, United States
Combat Group
๐บ๐ธLos Angeles, California, United States
Cedars Sinai Med Ctr
๐บ๐ธLos Angeles, California, United States
Highland Gen Hosp / San Francisco Gen Hosp
๐บ๐ธOakland, California, United States
HIV Research Group
๐บ๐ธSan Diego, California, United States
UCSD / Ctr for Special Immunology
๐บ๐ธSan Diego, California, United States
Saint Francis Mem Hosp
๐บ๐ธSan Francisco, California, United States
Scroll for more (33 remaining)McDowell Clinic๐บ๐ธPhoenix, Arizona, United States