Dyadic Neurofeedback for Emotion Regulation in Youth With Maternal Adversity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Emotional Dysfunction
- Sponsor
- Oklahoma State University Center for Health Sciences
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Blood Oxygen Level-Dependent (BOLD) signal changes (brain activation)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study will examine the effect of a real-time functional magnetic resonance imaging (fMRI) dyadic neurofeedback protocol with mothers and their adolescent daughters. Mothers will view a moving bar showing their daughters' brain activity on a computer screen while talking to their daughters.
Detailed Description
The current study will determine the effects of a real-time functional magnetic resonance imaging dyadic neurofeedback (rtfMRI-DNF) protocol that will train mothers with a history of adverse childhood experiences (ACEs) to regulate adolescents' activation in the anterior insular cortex (aIC) - a key brain region for ER. The proposed study will test the efficacy of this protocol to promote healthy ER-related neurodevelopment in adolescents with a maternal history of adversity. The proposed study will use DNF to provide neurofeedback from the adolescent's aIC to the parent as the parent and adolescent engage in an emotion discussion task together. Parents and adolescents (n=10 dyads) will communicate via microphones and noise-canceling headphones while the adolescent is undergoing fMRI scanning. Specific aims of the current study are: (1) to determine the brain response to aIC DNF adolescents, and (2) to determine effects of DNF on parenting behaviors. This study is significant because engaging with parents in DNF can promote positive ER development in adolescents at risk due to the intergenerational effects of ACEs.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All participants inclusion criteria:
- •Biological female
- •Sufficient English fluency to complete tasks
- •Co-residing at least 4 days per week
- •Inclusion criteria for adult participants:
- •Primary caregiver for more than 50% of child's lifespan
- •History of at least two adverse childhood experiences
- •Biological parent of adolescent participant
- •Inclusion criteria for adolescents:
- •Eligible for fMRI
Exclusion Criteria
- •Exclusion criteria for all participants:
- •Current psychiatric diagnosis
- •Exclusion criteria for adolescent participants:
- •Neurodevelopmental delay
- •History of psychiatric disorder
- •Medications influencing fMRI
- •Medical conditions influencing fMRI
Outcomes
Primary Outcomes
Blood Oxygen Level-Dependent (BOLD) signal changes (brain activation)
Time Frame: One hour (measured during second scan session)
Activation in the brain region targeted for neurofeedback and associated regions at Session 2. We hypothesize that lower activity will indicate a better outcome.
Parent validating statements (change over time)
Time Frame: Change in frequency in validation as coded by the manual over one week, from Session 1 to Session 2. Validating statements are measured and recorded during the scan sessions.
Validating statements made by the parent participant during the scan sessions. Statements will be coded using the Parent-Child Validation/Invalidation Behavior Coding Scales (Schneider \& Fruzzetti, 2002). Higher scores are indicative of a better outcome.
Resting-state network activity (change over time)
Time Frame: Change in resting-state activity over one week, from Session 1 to Session 2. Resting-state scan will last approximately 8 minutes.
Brain activity during fMRI resting-state scan
Secondary Outcomes
- Parenting behaviors (change over time)(Measured at the first research session and biweekly for two months)
- Depressive symptoms (change over time)(Measured at the first research session and biweekly for two months)
- Emotion regulation (change over time)(Measured at the first research session and biweekly for two months)