Dyadic Neurofeedback for Development of Healthy Emotion Regulation in Youth
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Emotional Regulation
- Sponsor
- Oklahoma State University Center for Health Sciences
- Enrollment
- 210
- Locations
- 1
- Primary Endpoint
- Resting-state network activity
- Status
- Active, not recruiting
- Last Updated
- 9 months ago
Overview
Brief Summary
This study will examine the effect of a real-time functional magnetic resonance imaging (fMRI) dyadic neurofeedback protocol with mothers and their adolescent daughters. Mothers in the experimental condition will view a moving bar showing their daughters' brain activity on a computer screen while talking to their daughters.
Detailed Description
Adolescents with a family history of adverse childhood experiences (ACEs) are at heightened risk for depression and other mental health problems related to poor emotion regulation (ER). The proposed study will test the efficacy of a real-time fMRI dyadic neurofeedback (DNF) protocol to promote healthy ER-related neurodevelopment in female adolescents with a maternal history of ACEs. The proposed study will use DNF to provide neurofeedback from the adolescent's anterior insular cortex (aIC) to the adolescent's mother as the mother and adolescent engage in an emotion discussion task together. Parents and adolescents (n=35 active DNF; n=35 control) will communicate via microphones and noise-canceling headphones while the adolescent is undergoing fMRI scanning. Specific aims of the current study are to determine: 1) the effects of aIC DNF on the developing ER network in adolescents with a history of maternal ACEs, 2) associations between parenting practices during DNF and reduced adolescent aIC activation, and 3) longitudinal effects of aIC DNF on adolescent internalizing symptoms.
Investigators
Kara Kerr
Assistant Professor
Oklahoma State University
Eligibility Criteria
Inclusion Criteria
- •All participants inclusion criteria:
- •Biological female
- •Sufficient English fluency to complete tasks
- •Co-residing at least 4 days per week
- •Inclusion criteria for adult participants:
- •Primary caregiver for more than 50% of child's lifespan
- •History of at least two adverse childhood experiences
- •Biological parent of adolescent participant
- •Inclusion criteria for adolescents:
- •Eligible for fMRI
Exclusion Criteria
- •Exclusion criteria for adolescent participants:
- •Current or past psychiatric disorder
- •Neurodevelopmental delay
- •Medications influencing fMRI
- •Medical conditions influencing fMRI
Outcomes
Primary Outcomes
Resting-state network activity
Time Frame: One year (change from first scan session to one-year follow-up)
Brain activity during fMRI resting-state scan
Blood Oxygen Level-Dependent (BOLD) signal changes (brain activation)
Time Frame: One hour (measured during one scan session)
Activation in the right anterior insular cortex and associated regions. We hypothesize that lower activity will indicate a better outcome.
Secondary Outcomes
- Emotion regulation (change over time)(One year (change from first scan session to one-year follow-up))
- Affect variability (change over time)(Two weeks)
- Depressive symptoms (change over time)(One year (change from first scan session to one-year follow-up))
- Parenting behaviors (change over time)(One year (change from first scan session to one-year follow-up))
- Parent-adolescent interaction quality (change over time)(Two weeks)