The Effects of Platelet-Rich Fibrin on Palatal Wound Healing After Free Gingival Graft Harvesting: A Comparative Randomized Controlled Clinical Trial
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Gingival Recession
- Sponsor
- Cukurova University
- Enrollment
- 125
- Primary Endpoint
- Epithelialization
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
Backgroung: Various agents are used to reduce post-operative complications associated with palatal donor site surgery for free gingival graft (FGG) harvesting. This study was conducted to evaluate the effects of platelet-rich fibrin (PRF) on palatal wound healing.
Detailed Description
125 patients with isolated recessions were treated. The connective tissue graft was obtained by the de-epithelialization of a free gingival graft in both groups. Three different hemostatic treatments were randomized; PRF with cyanoacrilate adhesive (PRF group, n:42), cyanoacrilate adhesive alone (BC group, n:42) and sterile wet gauze compression (WG group, n:41). Immediate and delayed bleeding, pain, epithelialization, feeding habits and sensation scores were recorded for different time points.
Investigators
Onur Ozcelik
Professor
Cukurova University
Eligibility Criteria
Inclusion Criteria
- •no contraindications for periodontal surgery;
- •full-mouth plaque score of \<10%
- •full-mouth bleeding score of \<15%.
Exclusion Criteria
- •previously undergone surgery for a graft harvested from the palate
- •presence of systemic disease or taking medication known to interfere with periodontal health
- •possible coagulation disorders
Outcomes
Primary Outcomes
Epithelialization
Time Frame: One month
Assessed according to the toluedine blue coloring
Secondary Outcomes
- Delayed bleeding(1 week)
- feeding habits(One month)
- Sensibility disorders(One month)
- Pain(3 months)
- Immediate Bleeding(1 hour)